However, with some small changes in your Skype app and Windows PC settings, you can disable Skype on startup. The automatic launch of the Skype program during startup can often slow down your computer, and you are stuck with endless buffering while opening any other applications. Well, there are different ways to stop Skype from starting automatically in Windows 10. The app is really helpful for communication, but it can get annoying when it starts automatically every time you turn on the computer. Skype comes pre-installed on many Windows 10 PCs, and if it doesn’t, users download it on purpose.